This screen ranks stocks on US OTC markets by return on invested capital (ROIC), highest first, and shows the top 100. ROIC measures how much profit a company earns on the debt and equity invested in it, and a ROIC well above the cost of capital is a mark of a high-quality business with a competitive edge. Very high values can come from a small capital base, so check consistency over several years. OTC stocks trade outside the major exchanges and are often thinly traded penny stocks; the list covers US OTC stocks with at least $100,000 in average daily trading value.